Changing Alanine (Ala, A) to Tryptophan (Trp, W)

Values are log-odds differences when comparing the two amino acids (second - first). The values for each amino acid are in the images below. High (green) values indicate changes that are favored by the mutations, low (red) values are those disfavored (i.e. favored by the wild type). Note that these values do not mean that a change will induce or disrupt binding to the elements above necessarily. Whether the impact is felt depends on what the particular amino acid position actually does. For instance, the DNA-binding values would apply if you think that the position of interest is at or near a DNA binding site.